HomeInvestor Lists › San Francisco Series-A VCs

San Francisco Series-A VCs

A curated list of active San Francisco Series-A VCs investing in startups.

by Tzakhi Freedman · December 9, 2025


Today, we selected 10 active San Francisco Series-A VCs from our database, investing in startups.

Our team reviewed, checked, and enriched the list with the necessary data.

Here goes:

• Climactic VC, Based in San Francisco, Climactic VC invests at the A-round stage in visionary founders tackling climate change and sustainability. The firm supports companies developing transformative technologies to address the planet’s most urgent environmental challenges.

• Climate Tech Circle, San Francisco’s Climate Tech Circle is a venture capital firm focused on early-stage climate technology. Through its Circle Fund, it enables climate investors to participate in scalable, impactful innovation combating global environmental issues.

• Common Sense Growth, Headquartered in San Francisco, Common Sense Growth invests at the A-round stage in media and entertainment ventures. As a subsidiary of Common Sense Media, it backs products and services that empower kids and families to thrive in the digital era.

• Counterpart Ventures, San Francisco-based Counterpart Ventures is a life cycle VC fund investing at the A-round stage. It focuses on building authentic, trust-based relationships with founders to support durable, long-term company growth.

• DCVC Bio, Operating from San Francisco, DCVC Bio invests at the A-round stage in life science ventures powered by deep tech. The firm backs startups leveraging advanced technologies to accelerate innovation across healthcare and biotechnology.

• Define Ventures, San Francisco’s Define Ventures is an early-stage VC firm focused on digital health. Investing at the A-round stage, it supports healthcare entrepreneurs who are transforming patient experiences and improving health outcomes through technology.

• Derive Ventures, Based in San Francisco, Derive Ventures invests at the A-round stage in hospitality, travel, and leisure startups. The firm targets innovative business concepts reshaping core travel sectors and helps founders navigate this complex global industry.

• Dolby Family Ventures, San Francisco-based Dolby Family Ventures is an early-stage VC firm dedicated to building great technology companies. It invests at the A-round stage, continuing the Dolby family’s legacy of supporting innovation and creativity in tech.

• Draft Ventures, Based in San Francisco, Draft Ventures is a collaborative online fund investing at the A-round stage in fintech and climate. It finances, advises, and accelerates early-stage companies working toward scalable, sustainable innovation.

• Ecosystem Integrity Fund, San Francisco’s Ecosystem Integrity Fund is a venture capital firm investing at the A-round stage in renewable energy and green chemistry. It targets sectors driving ecological sustainability and the transition to a low-carbon economy.

We have also put together a list of 200 impact and climate investors.

Our premium subscribers can access the list with all of the necessary data, including:

Name, website, HQ location, LinkedIn company page, description/thesis, preferred stages, preferred domains, and contact email.

To view the full premium list, upgrade now at a no-brainer price:

That’s all for today. Have a great day!

Tzakhi

PS: Want more? Download our full startup investor database with 16,000+ investors. Get it now→

Full USA VC & Startup Investor Database
3,111 firms · 6,505 decision-maker contacts · Immediate Excel file download.
$497 one-time
Download the Full Database →
Instant Excel download · Secure checkout

Get lists like this in your inbox, plus a free 100-VC sample